It's pretty close with Angel and Spike, but Xander and Spike had more scenes that were... less hateful than others. :P

xander had a young adult relationship with spike. where he had a schholbopy relationship with angel. xander and spike had to team up to take care of dawn and were forced to spend alot of time together in season7

i hate to say it but angel and xander just DIDNT GET ON AT ALL!! there were moments where xander was concerned about angel gonna die in the third season and wants to help angel too but once angel is forced to feed on buffy to save himself...hello again to snippy bitchy xander LOL BOYS!!! man they are just lil old ladies! haha!!

He was always complaining about Buffy's and Angel's relationship and he was always saying that Angel was dangerous and he would become Angelus and kill them all. He hated Spike too, but in the beginning he wasn't aware of his "relationship" with Buffy and didn't complain too much.

epic pic of spike there btw haha