I would pick Cruella because I hate animal cruelty, what Frollo does (did??) was far, far worse.

Or Frollo.

lol Makicious. That's exactly the sort of thing I'd do. XD

I recall almost nominating this villain myself. She's on a different kind of killing spree; she's all about murder in the name of fashion, but doesn't even bother to do the dirty work herself and instead calls upon her lackeys to do it for her. As for the quantity of murders she's trying to get them to commit in just one movie... yikes! Not to mention the evidence that these killing sprees are the norm for her lifestyle ("I live for furs! I worship furs!") it's all very disturbing.

All that said, I do consider her character to be a wake-up call for viewers who purchase a lot of things made of fur, leather, ivory, etc. without considering where these resources come from, despite the purchasers not meaning any intentional harm towards animals. Cruella herself may be evil, but she does raise awareness of animal cruelty!