I completely missed the George and Izzie break-up. When she kissed Alex in the season 4 finale, I was like: oy, she is together with George.. But somehow there was no GeorgexIzzie Amore interaction anymore...so when did they break up? :S
best couple on Grey's da far. i wanted them to get together from giorno 1, and they DEFINITELY had chemistry...they were PERFECT for each other!! the writers screwed this up they would have been an amazing couple...and i also hate how they weren't Friends anymore after they broke up!!! this was done all wrong, stupid writers!!! ) but apparently Izzie leaves and George DIES!?!?!?!? what the hell!?!????