What are the best moments in My Little pony for you?

Hard to say. Here are a few moments (Spoilers)
Twilight becoming an Alicorn
The fight between Twilight and Terik
When the CMC got their cutie marks
Maud Pie..... Just every scene with her in general
Amending Fences... all of it

Make New Friends But Keep Discord

Rarity: *Stuck in the smooze* Oh no! My dress is getting dirty!
Applejack: *Next to her* That's what you're afraid of? Really?

Do Princesses Dream Of Magic Sheep: Giant Derpy!

And of course, Con Mane from MMMystery Of The Friendship Express

CMC getting their Cutie Marks.

I Amore almost everything in this show, but this was the secondo biggest reaction the mostra has ever gotten out of me.

The first was when Tirek blew up Golden Oaks Library, but that wasn't exactly a happy moment, so I won't say it's the "best" moment.

I loved it when Discord made his first, and many appearances
Also when a new enemy appeared, which happened a lot

I loved the moment when Angel Sunset Shimmer fought and triumphed against witch Twilight Sparkle in Friendship Games, but the best moment for me was when the the CMC finally got their cutie marks. I was happier than a stoner getting stoned.