Gene Roddenberry had intended his new female communications officer to be called "Lieutenant Sulu". Herb Solow pointed out how similar this was to "Zulu" and thought it might act against the plan for racial diversity in the show, so the name Sulu remained with George Takei's character.

"Uhura" comes from the Swahili word uhuru, meaning "freedom". Nichols states in her book 'Beyond Uhura' that the name was inspired da her having had with her a copy of Robert Ruark's book Uhuru on the giorno she read for the part.

When producer Robert Justman explained to Roddenberry what the word uhuru meant, he changed it to Uhura and adopted that as the character's name.

Coincidentally, the end credits of the film stella, star Trek VI: The Undiscovered Country incorrectly refer to Uhura as "Uhuru".