Damn! That's a good question! It's hard to say. John/Bobby have way more experience, but we have really only seen Dean/Sam hunt, so I'd have to pick them.

i luv sam and dean so i have 2 say them but u have a good point about expirence. but then again sam and dean were raised to hunt so... shit idk!

john always got distracted (w/ good reason) but still.

Probably John and Bobby but anyways..

dean and sam definately because they...
1) know what there fighting and how to fight it
2) there sooo sexy
3) they are GREAT hunters :D
LOVE SUPERNATURAL <3

RiceCakes has a point. We've never really seen John and Bobby hunting.

I pick John & Bobby. I know we've never seen them hunt but they're the ones who taught Sam & Dean and the boys are like 2 of the best hunters now. Plus Bobbys really smart and has a ton of supernatural knowledge