I know right! Roy is definitely the best (and only) choice for Ed! I could never see anyone else with Ed. Especially not his brother. xD Incest is disturbing.
Well, there's marmellata, marmellata d'arance Boy, but after 3 seasons the boy & girl end up with different people. It was a very well-told convoluted Amore pentacle.
Hunter x Hunter offers a platonic bromance, with Killua being on the obsessive side.
It's tough...I really can't think of any hetero ones & all the gay ones are short stories in single volume mangas. When it's a boy & a girl, the best friend always looses to the bad boy o if he gets the girl, they weren't really very close as friends.
I'm trying to think of one where they knew eachother as kids.
well,... me and my bestfriend before :-( but she has a new one now :-) .... oh.... . . and my answer is honami(right) and adelicia(left) both in Amore with itsuki(middle)